Regulation of aminopeptidase N (EC 3.4.11.2; APN; CD13) by interferon-γ on the HL-60 cell line
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چکیده
منابع مشابه
Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes
Aminopeptidase N/CD13 is highly expressed by fibroblast like synoviocytes (FLS) and may play a role in rheumatoid arthritis (RA). CD13 was previously detected in human synovial fluid where it was significantly increased in RA compared to osteoarthritis. In this study we found that CD13 in biological fluids (plasma, synovial fluid, FLS culture supernatant) is present as both a soluble molecule a...
متن کاملReduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC.
Meningiomas are the second most common brain tumors in adults, and meningiomas exhibit a tendency to invade adjacent structures. Compared with high-grade gliomas, little is known about the molecular changes that potentially underlie the invasive behavior of meningiomas. In this study, we examined the expression and function of the membrane alanyl-aminopeptidase [mAAP, aminopeptidase N (APN), CD...
متن کاملNovel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis.
Aminopeptidase N (APN)/CD13 is a widely expressed transmembrane protein and its altered expression has been detected in various cancer cells. Several APN inhibitors have been developed and some of them have been found to have effectiveness as anti-cancer agents. This article reports anti-cancer effects of a hydroxamic acid derivative 24F that was newly-synthesized as an APN inhibitor. 24F had t...
متن کاملThe Netosis Formation of HL-60 Cell Differentiated to Neutrophil-Like Cells by LPS
Background: Neutrophils are the most abundant white blood cells in humans. Recently, a novel strategy called the formation neutrophil extracellular traps (NETs) was described. NETs is a new strategy for pathogen response. This study focused on whether LPS induced NETs release in vitro in the HL60 cell line. Methods: In this study, the HL60 cell line was used for culture and DMSO for induction ...
متن کاملLeukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.
BACKGROUND Attachment of leukemic cells to vascular endothelial cells induces the vascular endothelial cells to release endothelial cell-derived interleukin 8 (endothelial IL-8), which then induces leukemic cells to undergo apoptosis. NB4, a human promyelocytic leukemic cell line that expresses high levels of cell-surface CD13/aminopeptidase N, does not undergo endothelial IL-8-induced apoptosi...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2005
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2004.09.040